Analysis of Sera of Recipients with Allograft Rejection Indicates That Keratin 1 Is the Target of Anti-Endothelial Antibodies

Figure 5

Incidence of KRT1-specific antibodies in kidney transplant recipient serum samples. (a) Serum samples were analyzed using ELISAs for three KRT1 recombinants (KRT1-WT, KRT1-MU, and KRT1-DEL) and ATG8/GABARAPL1. The absorbance at 405 nm is plotted as a function of concentration of serum S5. (b) Percentages of KRT1-positive recipients in AECA-positive and AECA-negative groups. (c) Percentages of KRT1-positive recipients in subjects with serum creatinine level ≤ 120 μmol/L and subjects with serum creatinine level > 120 μmol/L. The statistic values are given.

(a)

(b)

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