Analysis of Sera of Recipients with Allograft Rejection Indicates That Keratin 1 Is the Target of Anti-Endothelial Antibodies

Table 1

Characteristics of selected sera from patients with kidney allografts undergoing rejection.

Patient serum (number)	Age (year)	Sex	Donor type	Tx (years)	Serum cr. (umol/L)	C4d	Anti-HLA-I	Anti-HLA-II	Anti-MICA	Anti-HUVEC	Anti-EC (platelets absorbed)
s1	46	F	LRD	7	561	+	A2	−	−	+	−
s2	50	F	LRD	5	462	−	−	DR4,7,9	−	−	−
s3	41	M	CAD	10	639	+	−	−	MICA-G1	+	+
s4	42	F	CAD	10	572	+	B5	−	−	+	+
s5	51	M	CAD	0.5	974	+	−	−	−	+	+

: cadaveric donor; LRD: living related donor; multiple human platelets were used to remove anti-HLA-I antibodies from serum.