Computational Approaches to Facilitate Epitope-Based HLA Matching in Solid Organ Transplantation

Figure 2

Comparison of the delta in ln(PIRCHE-II) and the delta in ln(eplet). (a) When using serological split level HLA typing of both donor and recipient, the majority of the donor-recipient couples had a comparable ln(PIRCHE-II) and ln(eplet) delta. For 13 donor-recipient couples, the observed ln(PIRCHE-II) or ln(eplet) values deviated substantially (>+1 or <−1) from the reference ln(PIRCHE-II) or ln(eplet) values. (b) When using two-field resolution HLA genotype data of the recipient and serological split level HLA typing of donor the deviation between the observed ln(PIRCHE-II)/ln(eplet) values and the reference ln(PIRCHE-II)/ln(eplet) values substantially diminished. The dashed squares indicate the delta<0.5 and delta<1 borders.

(a)

(b)