Chinese Herbal Formula, Modified Danggui Buxue Tang, Attenuates Apoptosis of Hematopoietic Stem Cells in Immune-Mediated Aplastic Anemia Mouse Model

<div>DGBX attenuates interferon <i>γ</i> (IFN<i>γ</i>) expression by regulating the activation of SLAM/SAP signal. (a) BMCs were stained for CD150/SLAM (red) and SH2D1A/SAP (green) antibodies and observed by confocal immunofluorescence microscopy. The bottom pictures were obtained in bright field. The double-stained cells (yellow) were quantified with ImageJ. (b) Results are presented in the bar charts. The scale bar corresponds to 100 <i>μ</i>m throughout. A, normal group, B, model group, C, group treated with cyclosporin A, and D, group treated with DGBX. (c) Fyn was assessed in whole BMC lysates by Western blot analysis. (d) The results are presented in the bar chart. GAPDH was used as an internal control. 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Journal of Immunology Research

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Figure 5

Figure 5: Chinese Herbal Formula, Modified Danggui Buxue Tang, Attenuates Apoptosis of Hematopoietic Stem Cells in Immune-Mediated Aplastic Anemia Mouse Model 

Figure 5 | Chinese Herbal Formula, Modified Danggui Buxue Tang, Attenuates Apoptosis of Hematopoietic Stem Cells in Immune-Mediated Aplastic Anemia Mouse Model 