Adrenomedullin Regulates IL-1β Gene Expression in F4/80+ Macrophages during Synovial Inflammation

Figure 4

Effects of interleukin- (IL-) 1β on IL-1β, adrenomedullin (AM), and receptor activity-modifying protein 2 (RAMP2), and RAMP3 gene expression in cultured primary synovial fibroblasts and macrophages. The effects of IL-1β on F4/80 (a), IL-1β (b), AM (c), RAMP2 (d) and RAMP3 (e) gene expression in cultured primary synovial fibroblasts (F4/80-negative fraction) and macrophages (F4/80-positive fraction) were examined by real-time PCR. compared with F4/80-negative fraction. compared with fraction matched-untreated controls.

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