Two-Parametric Immunological Score Development for Assessing Renal Involvement and Disease Activity in Systemic Lupus Erythematosus

Figure 2

Likelihood plots for the assessment of disease activity, lupus nephritis, and lupus nephritis activity; likelihood ratios are shown as a function of antibody titer. Likelihood plots of the QUANTA Flash (QF) dsDNA, QUANTA Lite (QL) C1q, and anti-Ku chemiluminescent immunoassay (CIA) for disease activity (a–c), lupus nephritis (d–f), and lupus nephritis activity (g–i). The black line indicates the odds ratios (OR), while the red and blue lines denote the positive and negative likelihood ratios, respectively. Furthermore, the green vertical line represents the manufacturer’s cut-off point. The acronyms IU/mL and RLU stand for international units/mL and relative light units, respectively, which are assay unit values generated from the QF CIA technology.

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