Inhibition of IL-17 and IL-23 in Human Keratinocytes by the A₃ Adenosine Receptor Agonist Piclidenoson

Figure 5

Piclidenoson downregulates IL-17 and IL-23. HaCat cells were incubated in the presence and absence of piclidenoson (10 nM) and MRS 1523 (50 nM) for 48 hours. The expression level of the inflammatory cytokines IL-17 and IL-23 was tested by Western blot analysis.