Downregulation of iNOS, IL-1<i>β</i>, and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats

<div>Cultured rat BMMCs expressed tryptase, PAR4, iNOS, and P2X7. (a–c) Expression of tryptase (AA1) and its colocalization with PAR4, iNOS, or P2X7 in cultured BMMCs (bar 100 <i>μ</i>m). (d) Flow cytometric analysis showed that the BMMCs expressed relatively high levels of tryptase, PAR4, iNOS, and P2X7.</div>

Journal of Immunology Research

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Figure 4

Figure 4: Downregulation of iNOS, IL-1<i>β</i>, and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats 

Figure 4 | Downregulation of iNOS, IL-1β, and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats 