Immunotherapy with Native Molecule rather than Hypoallergenic Variant of Pru p 3, the Major Peach Allergen, Shows Beneficial Effects in Mice

Figure 3

SCIT with Pru p 3, but not with R/A Pru p 3, induced production of Th1-type IgG Abs. After the sensitization with Pru p 3, BALB/c mice received SCIT with 10 or 100 μg of Pru p 3 or R/A Pru p 3 and challenged with Pru p 3. The serum levels of (a) Pru p 3-specific IgE, (b) IgG1, and (c) IgG2a Abs were measured by ELISA.

(a)

(b)

(c)