Lymph Node-Targeting Nanovaccine through Antigen-CpG Self-Assembly Potentiates Cytotoxic T Cell Activation

Figure 1

A schematic diagram of OVA-CpG NP fabrication and vaccine immunization strategy. First, GSH was added to change the charge of OVA to positive. Then, an electrostatic interaction could be triggered with the further addition of negatively charged CpG, and the OVA-CpG NPs could self-assemble. After subcutaneous (sc) injection, OVA-CpG NPs drained to lymph nodes and stimulated the maturation of DCs. Then, an effective T cell immune response was aroused to kill tumor cells.