Research Article
Neuroblastoma Cell Lines Are Refractory to Genotoxic Drug-Mediated Induction of Ligands for NK Cell-Activating Receptors
Table 1
Status of ATM, ATR, CHEK1, and CHEK2 genes in NB cells.
| | NB cell lines | ATM gene | Chromosomal coordinates of ATM loss/cnLOH | ATR gene | Chromosomal coordinates of ATR gain | CHEK1 gene | Chromosomal coordinates of CHEK1 loss/cnLOH | CHEK2
gene | Chromosomal coordinates of CHEK2 loss |
| | SK-N-AS | Loss | Chr11: 72159638–134720344
Cytoband: 11q13.4–q25
Size: 62.5 Mb | Gain | Chr3: 94300781–197840323
Cytoband: 3q11.2–q29
Size: 103.5 Mb | Loss | Chr11: 72159638–134720344
Cytoband: 11q13.4–q25
Size: 62.5 Mb | Loss | Chr22: 23283056–31436822
Cytoband: 22q11.22–q12.2
Size: 8.1 Mb | | SH-SY5Y | Single copy | — | Single copy | — | Single copy | — | Single copy | — | | SH-EP | Loss | Chr11: 93455106–119038765
Cytoband: 11q21–q23.3
Size: 25.6 Mb | Gain | Chr3: 133671502–197801441
Cytoband: 3q22.1–q29
Size: 64.1 Mb | Single copy | — | Single copy | — | | SK-N-SH | Single copy | — | Single copy | — | Single copy | — | Single copy | — | | SK-N-BE(2)c | Copy-neutral LOH | Chr11: 55196818–134924542
Cytoband: 11q13.2–q24.3
Size: 79.7 Mb | Single copy | — | Copy neutral LOH | Chr11: 55196818–134924542
Cytoband: 11q13.2–q24.3
Size: 79.7 Mb | Loss | Chr22: 16153099–51224252
Cytoband: 22q11.1–q13.33
Size: 35.0 Mb | | LA-N-5 | Single copy | — | Single copy | — | Single copy | — | Single copy | — | | IMR-32 | Loss | Chr11: 85989063–134446160
Cytoband: 11q14.2–q25
Size: 48.4 Mb | Single copy | — | Loss | Chr11: 85989063–134446160
Cytoband: 11q14.2–q25
Size: 48.4 Mb | Single copy | — |
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