Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1

Figure 4

Common highly linked molecules and their most significantly related signaling pathways and functions in the “matrine-CRC” merged network. In the network, molecules are nodes, and biological relationships between two nodes are represented by lines. Solid lines between molecules show a direct physical relationship, whereas dotted lines show indirect functional relationships. (a) The five blue molecules in the center of the network represent common highly linked molecules. Red molecules represent CRC-related genes, and green molecules represent matrine-related proteins in the surrounding area of the network. In the Ingenuity Knowledge Database, “CP” is an abbreviation for “canonical pathway,” which represents a signaling pathway related to the highly linked molecules. “FC” is an abbreviation for “functional characteristic,” which represents functions related to the highly linked molecules. (b) Purple symbols represent highly linked molecules, and yellow symbols represent the molecules in the HMGB1 signaling pathway.

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