CD47 Blockade Inhibits Tumor Progression through Promoting Phagocytosis of Tumor Cells by M2 Polarized Macrophages in Endometrial Cancer

Figure 1

The majority of infiltrated macrophages in EC tissues are M2 TAMs. (a) Representative immunohistochemical staining of CD68 and CD163 (400x) in normal, EAH, and EC tissues. CD68 (a–c) and CD163 (d–f). Scale bars, 20 μm. (b–c) Cell counts of CD68⁺ and CD163⁺ macrophages. (d) Representative images of CD68⁺CD163⁻ macrophages (M1 macrophages) and CD163⁺CD68⁺ macrophages (M2 macrophages). Scale bars, 20 μm. (e) The ratio of CD163⁺ to CD68⁺ cells (M2/total macrophage ratio). There were 26 normal endometrium samples, 11 EAH samples, and 47 EC samples. Data were shown as the mean ± SEM (ns, not significant; and ).

(a)

(b)

(c)

(d)

(e)