CD47 Blockade Inhibits Tumor Progression through Promoting Phagocytosis of Tumor Cells by M2 Polarized Macrophages in Endometrial Cancer

Figure 6

CD47 knockdown inhibits EC growth in vivo and promotes the infiltration of M1 macrophages in tumors. (a) Tumor volumes of heterotopic xenografted tumors in NSG mice which were engrafted with CD47-knockdown Ishikawa cells or control Ishikawa cells measured every 7 days. (b) The body weight of the mice measured every 7 days. (c) Tumor volumes of different groups. (d) Representative images and cell counts of F4/80⁺ macrophages in tumor mass (200x). Scale bars, 50 μm. (e) Representative images and cell counts of iNOS⁺ macrophages in tumor mass (200x). Scale bars, 50 μm. (f) Representative images and cell counts of CD163⁺macrophages in tumor mass (200x). Scale bars, 50 μm. Data are shown as the mean ± SEM (ns, not significant; and ).

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