LCK as a Potential Therapeutic Target for Acute Rejection after Kidney Transplantation: A Bioinformatics Clue

Figure 2

Bubble charts of top 15 gene enrichment results in each category. Gene counts and values of top 15 enrichment terms in molecular function (MF), biological process (BP), cellular component (CC), and pathway analysis were shown in bubble charts. Gene counts in each term were displayed as the size of bubbles. Larger in size means larger numbers of genes in this term. The gradual color from red to green shows the changes of values from low to high. (a) Results of MF analysis. Most of DEGs clustered in protein homodimerization activity, while the antigen binding has the greatest statistical significance. (b) Results of BP analysis. The immune response presented the less value and the maximum of genes. (c) Results of CC analysis. Most of DEGs located on integral component of membrane, while the external side of plasma membrane showed the greatest significance in statistics. (d) Results of pathway analysis. Both the maximum of gene counts and lowest value appeared in the category of cytokine-cytokine receptor interaction.

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