FGFRL1 Promotes Ovarian Cancer Progression by Crosstalk with Hedgehog Signaling

Figure 5

FGFRL1 enhances the Hh signaling pathway. (a, b) Kyoto Encyclopedia of Genes and Genome (KEGG) analysis of cDNA microarray showed gene set enrichment after FGFRL1 knockdown in OVCAR8 and ES2 cells. (c) The GSEA plot based on the gene expression profiles by comparison of the lower FGFRL1 expression group and the higher FGFRL1 expression group in the GSE9891 dataset. (d) The Venn diagram of the significantly altered pathways in two OC cells and ovarian tissues. (e) The activity of the Hh signaling pathway was significantly inhibited after knockdown of FGFRL1 by a luciferase reporter assay. (f, g) The mRNA expression levels of target genes of the Hh signaling pathway in OC cell lines after knockdown of FGFRL1. (h) Schematic summary of the findings presented in this study on the role of FGFRL1 in OC. ; .

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