Impact of Bone Marrow Aspirate Tregs on the Response Rate of Younger Newly Diagnosed Acute Myeloid Leukemia Patients

Table 2

Factors affecting overall response.

	Response
	Yes	No
	Age
Years, median value	52	56	ns
WBC
WBC/μL, median value	9565	18430	ns
Molecular/cytogenetic group^@, (%)			0.027^b; 0.049^d
Poor	1 (10)	7 (54)
Intermediate	6 (60)	6 (46)
Good	3 (30)	0 (0)
NPM/FLT3, (%)
NPM^mut	6 (60)	0 (0)	0.002^c; 0.001^d
NPM^wt	4 (40)	13 (100)
FLT3 ITD+ or D835+	1 (10)	4 (31)	ns
FLT3^wt	9 (90)	9 (69)
NPM^mut/FLT3^wt/NK	3 (30)	0 (0)	ns
No (NPM^mut/FLT3^wt/Nk)	7 (70)	13 (100)
dBMA Tregs^#, (%)			0.036^c; ns^d
<21/μL	2 (20)	9 (69)
≥21/μL	8 (80)	4 (31)
De novo AML, (%)			0.046^c; ns^d
Yes	10 (100)	8 (61)
No	0 (0)	5 (39)

^@According to ELN 2010 [ITD allelic ratio not performed]. ^bChi-square test. ^cFisher exact test. ^dMultivariate stepwise-backward elimination procedure. Bold values are statistically significant (). WBC: white blood cells; dBMA Tregs: diagnostic bone marrow aspirate T regulatory cells; NK: normal karyotype; AML: acute myeloid leukemia.