Evaluation of EBV- and HCMV-Specific T Cell Responses in Systemic Lupus Erythematosus (SLE) Patients Using a Normalized Enzyme-Linked Immunospot (ELISPOT) Assay

Table 1

Characteristics of study population.

	SLE patients (70)	Healthy subjects (50)	value
Gender (female/male)	64/6	35/15	0.0032
Age (years, median (IQR))	46.5 (38.0-57.8)	44 (34.8-50.0)	0.1174
Serology
EBV-seropositive	68	46
EBV-seronegative	2	4	0.2331
HCMV-seropositive	56	35
HCMV-seronegative	14	15	0.2795
DNAemia
EBV DNA-positive	30	4	<0.0001
HCMV DNA-positive	3	0	0.2821
Viral load
EBV DNA (copies/ml, median (IQR))	233 (100-656.3)	125 (62.5-225)	0.1895
HCMV DNA (copies/ml, median (IQR))	200 (100-1000)	Undetectable
Immunosuppression
lp-IS	25
mhp-IS	45
SLEDAI score
<4	45
≥4	25

Demographic characteristics of SLE population and healthy controls are summarized in the table. () values were calculated using Fisher’s exact test.