The IL-1B Gene Polymorphisms rs16944 and rs1143627 Contribute to an Increased Risk of Coronary Artery Lesions in Southern Chinese Children with Kawasaki Disease
Table 2
Genotype distributions of IL-1B gene polymorphisms and Kawasaki disease susceptibility.
Genotype
Cases ()
Controls ()
a
Crude OR (95% CI)
Adjusted OR (95% CI)b
b
rs16944 ()
AA
154 (21.42)
342 (24.41)
1.00
1.00
AG
367 (51.04)
682 (48.68)
1.20 (0.95-1.50)
0.127
1.20 (0.95-1.51)
0.120
GG
198 (27.54)
377 (27.91)
0.24 (0.90-1.51)
0.240
1.17 (0.90-1.51)
0.233
Additive
0.294
1.08 (0.95-1.22)
0.266
1.08 (0.95-1.22)
0.260
Dominant
565 (78.58)
1,059 (75.59)
0.122
1.19 (0.95-1.47)
0.124
1.19 (0.96-1.48)
0.118
Recessive
521 (72.46)
1,024 (73.09)
0.758
1.03 (0.84-1.26)
0.757
1.03 (0.84-1.26)
0.758
rs1143627 ()
GG
156 (21.70)
350 (24.98)
1.00
1.00
AG
371 (51.60)
687 (49.04)
1.21 (0.97-1.52)
0.098
1.21 (0.97-1.53)
0.091
AA
192 (26.70)
364 (25.98)
1.18 (0.92-1.53)
0.199
1.19 (0.92-1.54)
0.192
Additive
0.235
1.08 (0.95-1.23)
0.217
1.09 (0.96-1.23)
0.210
Dominant
563 (78.30)
1,051 (75.02)
0.091
1.20 (0.97-1.49)
0.093
1.21 (0.79-1.50)
0.087
Recessive
527 (73.30)
1,037 (74.02)
0.720
1.04 (0.85-1.27)
0.720
1.04 (0.85-1.27)
0.718
a test for genotype distributions between Kawasaki disease patients and controls. bAdjusted for age and gender.
