The IL-1B Gene Polymorphisms rs16944 and rs1143627 Contribute to an Increased Risk of Coronary Artery Lesions in Southern Chinese Children with Kawasaki Disease
Table 3
Genotype distributions of IL-1B gene polymorphisms and susceptibility to coronary artery lesions in Kawasaki disease.
Genotype
CALs ()
NCALs ()
a
Crude OR (95% CI)
Adjusted OR (95% CI)b
b
rs16944
AA
64 (20.51)
90 (22.11)
1.00
1.00
AG
154 (49.36)
213 (52.33)
1.02 (0.69-1.49)
0.932
1.01 (0.69-1.49)
0.941
GG
94 (30.13)
104 (25.55)
1.27 (0.83-1.94)
0.269
1.27 (0.83-1.94)
0.277
Additive
0.396
1.40 (0.92-1.40)
0.239
1.13 (0.92-1.40)
0.247
Dominant
248 (79.49)
317 (77.89)
0.604
1.10 (0.77-1.59)
0.604
1.10 (0.76-1.58)
0.616
Recessive
218 (69.87)
303 (74.45)
0.174
1.26 (0.90-1.75)
0.174
1.25 (0.90-1.74)
0.179
rs1143627
GG
65 (20.83)
91 (22.36)
1.00
1.00
AG
156 (50.00)
215 (52.83)
1.02 (0.70-1.48)
0.935
1.01 (0.69-1.48)
0.945
AA
91 (29.17)
101 (24.82)
1.26 (0.82-1.93)
0.286
1.26 (0.82-1.93)
0.291
Additive
0.426
1.13 (0.91-1.40)
0.261
1.13 (0.91-1.40)
0.266
Dominant
247 (79.17)
316 (77.64)
0.622
1.09 (0.76-1.57)
0.623
1.09 (0.76-1.57)
0.633
Recessive
221 (70.83)
306 (75.18)
0.192
2.16 (0.77-6.06)
0.146
1.25 (0.89-1.74)
0.194
CALs: coronary artery lesions; NCALs: no coronary artery lesions. a test for genotype distributions between Kawasaki disease patients and controls. bAdjusted for age and gender.
