Amiselimod (MT-1303), a Novel Sphingosine 1-Phosphate Receptor-1 Modulator, Potently Inhibits the Progression of Lupus Nephritis in Two Murine SLE Models

Figure 6

Effect of MT-1303 on the number of B cells and plasma cells in the spleen of NZBWF1 mice. MT-1303 at 0.3 mg/kg was orally administered to NZBWF1 mice for 13 weeks from 28 weeks of age. The spleen was obtained the day after the final administration. The number of B cells (a) and plasma cells (b) in the spleen was determined by flow cytometry. Results are expressed as the of 8 mice. Statistical differences were calculated using Student’s -test ().

(a)

(b)