CD38 Deficiency Downregulates the Onset and Pathogenesis of Collagen-Induced Arthritis through the NF-κB Pathway

Figure 5

Decreased phosphorylation of NF-κB in BMDCs generated over 7 days from CD38^-/- CIA mice. The protein was extracted from DCs in the WT and CD38^-/- mice with or without collagen stimuli. Expressions of NF-κB p65 (a), Phospho-NF-κB p65 (b), NF-κB1 p105 (c), Phospho-NF-κB1 p105 (d), and RelB (g) in WT CIA and CD38^-/- CIA mice were detected by Western blot ( per group/experiment). Expressions of NF-κB1 p105 (e) and Phospho-NF-κB1 p105 (f) in the WT and CD38^-/- healthy mice were also detected by Western blot as normal control ( per group/experiment).

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