Induction of Macrophage M2b/c Polarization by Adipose Tissue-Derived Mesenchymal Stem Cells

Figure 6

The mRNA expression in different groups of Mφ. IL-10 and SPHK-1 are M2b/c markers. IL-27, IGF-1, FIZZ-1, and Arg-1 are M2a markers. Compared with the control, LPS, and IL groups, Mφ in the CM, LPS-CM, and IL-CM groups upregulated their M2b/c marker mRNA expression, except SPHK-1 mRNA expression of the LPS-CM group. Compared with the control and LPS groups, Mφ in the CM and LPS-CM groups downregulated their M2a markers mRNA expression, except FIZZ1-1 and Arg-1 mRNA expression of the control group. The IL-CM group upregulated their M2a marker mRNA expression, except IGF-1, compared with the IL group.