Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice

<div>Constitutive TL1A expression on macrophages promoted the activation of HSCs. (a, c, e) The <i>α</i>-SMA expressions of HSCs cultured with BMM-derived CM in the CM/Tg group were markedly higher than those in the CM/WT group detected by immunofluorescence staining (400x) and RT-PCR. (b, d, f) The <i>α</i>-SMA expressions of HSCs cultured with PM-derived CM in the CM/Tg group were significantly higher than those in the CM/WT group detected by immunofluorescence staining (400x) and RT-PCR. 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Journal of Immunology Research

fig7

Figure 7

Figure 7: Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice 