Exploring the Role of C-C Motif Chemokine Ligand-2 Single Nucleotide Polymorphism in Pulmonary Tuberculosis: A Genetic Association Study from North India

Figure 1

Comparative analysis of serum CCL2 level in PTB patients and healthy controls. Serum CCL2 was measured by sandwich ELISA using Duoset from R&D Systems, USA, in pulmonary TB patients and controls. The level was expressed as pg/ml on the -axis and represented as box and whisker plot. Each dot above the vertical box plot represents the outside value of one subject. Each box is with whiskers on both sides with upper and lower adjacent values, respectively. The box shows the 75^th, median, and 25^th percentile values from the upper hinge to lower hinge, respectively. Subjects are represented on the -axis. HC: healthy controls; PTB: pulmonary TB patients; AA: subjects with CCL2-2518AA genotypes; AG: subjects with CCL2-2518AG genotype; GG: subjects with CCL2-2518GG genotypes. (a) For comparison of CCL2 level between HC and PTB patients. (b) For comparison of the CCL2 level among PTB patients having various CCL2 genotypes. (c) The comparison of the CCL2 level among HC having various genotypes. Pairwise comparison was made by the Wilcoxon rank-sum test, and comparison of groups was done by the Kruskal-Wallis equality of population rank test. values are shown above the box plots.

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