Exploring the Role of C-C Motif Chemokine Ligand-2 Single Nucleotide Polymorphism in Pulmonary Tuberculosis: A Genetic Association Study from North India

Table 2

Genotype analysis of CCL2-2518 A>G and-362 G>C polymorphisms in PTB cases and healthy control.

Genotype/allele	PTB cases	Healthy controls	Chi (DF)	OR (95% CI)	value
-2518 A>G	No (frequency)	No (frequency)
AA	214 (0.57)	126 (0.51)
AG	117 (0.31)	107 (0.43)
GG	42 (0.11)	15 (0.06)	11.31 (2)		0.004
A allele	545 (0.73)	359 (0.72)
G allele	201 (0.27)	137 (0.28)	0.07 (1)	0.0.97 (0.74-1.24)	0.79
		MH-OR (Adj. for sex)	0.02 (1)	0.98 (0.75-1.27)	0.88
Dominant model
AA	214 (0.57)	126 (0.51)
AG+GG	159 (0.43)	122 (0.49)	2.59 (1)	0.76 (0.55-1.06)	0.10
		MH-OR (Adj. for sex)	2.32 (1)	0.77 (0.55-1.07)	0.12
Overdominant model
AA+GG	256 (0.69)	141 (0.57)
AG	117 (0.31)	107 (0.43)	8.95 (1)	0.60 (0.43-0.84)	0.003
		MH-OR (Adj. for sex)	8.81 (1)	0.60 (0.42-0.84	0.003
Recessive model
AA+AG	331 (0.89)	233 (0.94)
GG	42 (0.11)	15 (0.06)	4.85 (1)	1.97 (1.06-3.64)	0.028
		MH-OR (Adj. for sex)	5.35 (1)	2.07 (1.10-3.91)	0.02
-362 G>C
GG	174 (0.53)	113 (0.48)
GC	114 (0.35)	105 (0.45)
CC	42 (0.13)	17 (0.07)	8.18 (2)		0.017
G allele	462 (0.70)	331 (0.70)
C allele	198 (0.30)	139 (0.30)	0.02 (1)	1.02 (0.78-1.3)	0.87
		MH-OR (Adj. for sex)	0.05 (1)	1.03 (0.79-1.33)	0.82
Dominant model
GG	174 (0.53)	113 (0.48)
GC+CC	156 (0.47)	122 (0.52)	1.18 (1)	0.83 (0.59-1.16)	0.27
		MH-OR (Adj. for sex)	1.13 (1)	0.83 (0.59-1.16)	0.28
Overdominant model
GG+CC	216 (0.65)	130 (0.55)
GC	114 (0.34)	105 (0.45)	5.93 (1)	0.65 (0.46-0.92)	0.015
		MH-OR (Adj. for sex)	6.15 (1)	0.64 (0.45-0.91)	0.013
Recessive model
GG+GC	288 (0.87)	218 (0.93)
CC	42 (0.13)	17 (0.07)	4.42 (1)	1.87 (1.03-3.38)	0.035
		MH-OR (Adj. for sex)	4.89 (1)	1.92 (1.06-3.47)	0.027