Epigenetic Therapy as a Putative Molecular Target to Modulate B Cell Biology and Behavior in the Context of Immunological Disorders

<div>HDAC activity is necessary for B1 cell behavior. Peritoneal cells were harvested from C57BL/6 male mice and cultured in medium (RPMI), medium+IL-5 (RPMI+IL-5), medium+iHDAC (RPMI+iHDAC), or medium+IL-5+iHDAC (RPMI+IL-5+iHDAC). Upon 48 hours in cell-free culture (a–e) or 24 hours on a feeder layer (h–j), B220<sup>+</sup> cells were quantified by flow cytometry and B1 cells (B220<sup>low</sup>/CD11b<sup>+</sup>) were phenotyped. 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Journal of Immunology Research

fig2

Figure 2

Figure 2: Epigenetic Therapy as a Putative Molecular Target to Modulate B Cell Biology and Behavior in the Context of Immunological Disorders 