Single Nucleotide Polymorphisms in TLR4 Affect Susceptibility to Tuberculosis in Mexican Population from the State of Veracruz
Table 2
Distribution of TLR1, TLR2, TLR4, TLR6, and TLR10 allele and genotype polymorphisms in TB patients and controls of the state of Veracruz.
Gene SNP
TB patients
Controls
OR (95% CI)
value
Frequency
Frequency
TLR1
CC
84
30.1
176
30.9
1
N248S (rs4833095)
CT
135
48.4
277
48.7
1.02 (0.72- 1.48)
0.88
TT
60
21.5
116
20.4
1.06 (0.68-1.64)
0.80
Dominant
TT+TC
195
393
1.03 (0.74-1.45)
0.84
C
303
54.3
629
55.3
1
T
255
45.7
509
44.7
1.04 (0.84- 1.28)
0.82
TLR2
GG
279
100
568
99.8
1
R753Q (rs5743708)
GA
0
0
1
0.2
—
ND
G
558
100
1137
99.9
1
A
0
0.00
1
0.1
—
ND
TLR4
AA
275
98.6
537
94.4
1
D299G (rs4986790)
AG
3
1.1
32
5.6
0.20 (0.06-0.69)
0.01
GG
1
0.4
0
0
—
ND
Dominant
GG+AG
4
32
0.26 (0.09-0.77)
0.02
A
553
99.1
1106
97.2
1
G
5
0.9
32
2.8
0.31 (0.09-0.81)
0.01
TLR4
CC
275
98.6
543
95.4
1
T399I (rs4986791)
CT
4
1.4
26
4.6
0.35 (0.13-0.90)
0.03
C
554
99.3
1112
97.7
1
T
4
0.7
26
2.3
0.29 (0.10-0.90)
0.03
TLR6
GG
236
84.6
488
85.8
1
S249P (rs5743810)
GA
42
15.1
78
13.7
1.15 (0.76-1.74)
0.30
AA
1
0.4
3
0.5
0.40 (0.04-4.29)
0.45
Dominant
AA+GA
43
81
1.22 (0.79-1.88)
0.38
G
514
92.1
1054
92.6
1
A
44
7.9
84
7.4
1.08 (0.72-1.60)
0.70
TLR10
CC
192
68.8
374
65.7
1
A163S (rs11466649)
CA
77
27.6
178
31.3
0.84 (0.60-1.18)
0.32
AA
10
3.6
17
3.0
1.09 (0.45-2.57)
0.86
Dominant
AA+CA
87
195
0.86 (0.62-1.20)
0.38
C
461
82.6
926
81.4
1
A
97
17.4
212
18.6
0.92 (0.70-1.20)
0.53
TLR10
CC
192
68.8
374
65.7
1
V298I (rs11466651)
CT
77
27.6
178
31.3
0.83 (0.60-1.18)
0.33
TT
10
3.6
17
3.0
1.08 (0.45-2.57)
0.86
Dominant
TT+CT
87
195
0.86 (0.62-1.20)
0.38
C
461
82.6
926
81.4
1
T
97
17.4
212
18.6
0.92 (0.70-1.20)
0.53
Abbreviations: TB: tuberculosis; OR: odds ratio; CI: confidence interval; ND: not determined. values adjusted for gender, speaking an indigenous language, and educational level were determined by multivariate logistic regression.
