Rotavirus VP6 Adjuvant Effect on Norovirus GII.4 Virus-Like Particle Uptake and Presentation by Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo

<div>Blocking antibody responses generated by <i>ex vivo</i>-pulsed BMDCs. Norovirus GII.4 virus-like particle- (VLP-) pulsed bone marrow-derived dendritic cells (BMDCs) were transferred intramuscularly two times to mice either alone (Gr II) and in combination with simultaneously (Gr III) or separately (Gr IV) VP6-pulsed BMDCs as described in <a href="https://static-preview.hindawi.com/articles/jir/volume-2020/3194704/figures/#sec2">Materials and Methods</a>. The immune sera of mice were tested individually 1 : 50 (a) or as a pool with serial dilutions (b) against GII.4 VLPs in blocking assays utilizing human saliva type A as the source of histoblood group antigens. 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transform="matrix(.013,0,0,-0.013,363.56,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,369.8,0)"><path d="M594 629L561 652L159 -9L190 -32L594 629ZM194 635C92 635 49 534 49 453C49 374 92 272 193 272C295 272 338 374 338 454S295 635 194 635ZM193 605C257 605 265 504 265 453C265 405 257 302 194 302C133 302 122 403 122 454S133 605 193 605ZM567 351C465 351 421 250 421 169C421 90 465 -12 566 -12S710 90 710 170S667 351 567 351ZM566 322C628 322 637 221 637 169C637 121 628 18 567 18S494 119 494 170C494 223 506 322 566 322Z"></path></g><g transform="matrix(.013,0,0,-0.013,379.628,0)"><path d="M226 -163V703H56V676C162 667 165 662 165 584V-43C165 -122 162 -126 56 -136V-163H226Z"></path></g></svg>.</span> The error bars represent the standard error between individual mice (a) or two independent assays (b), and the horizontal dashed line illustrates the blocking titer 50%.</div>

Journal of Immunology Research

fig8

Figure 8

Figure 8: Rotavirus VP6 Adjuvant Effect on Norovirus GII.4 Virus-Like Particle Uptake and Presentation by Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo 

Figure 8 | Rotavirus VP6 Adjuvant Effect on Norovirus GII.4 Virus-Like Particle Uptake and Presentation by Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo 