Probiotics Can Boost the Antitumor Immunity of CD8⁺T Cells in BALB/c Mice and Patients with Colorectal Carcinoma

Figure 4

Analysis of antitumor mechanism of CD8⁺T cells after probiotic intervention. After CT26 cells were inoculated subcutaneously on the back of BALB/c mice, they were fed with Bifidobacterium. After 3 days, the tumor tissues were removed and analyzed by flow cytometry. (a) The results of CD4⁺TIL and CD8⁺TIL in the Bifidobacterium-fed mice, (b) the results of CD4⁺TIL and CD8⁺TIL in the non-Bifidobacterium-fed mice, (c) the statistical results of CD4⁺TIL between group A and group B, (d) the statistical results of CD8⁺TIL between group A and group B, (e) the results of CD8⁺TIM-1⁺TIL in the Bifidobacterium-fed mice, (f) CD8⁺TIM-1⁺TIL in mice fed with nonbifidobacteria, (g) CD8⁺PD-1⁺TIL in mice fed with bifidobacteria, (h) CD8⁺PD-1⁺TIL in mice fed with nonbifidobacteria, (i) statistical result of TIM-1 expression, and (j) statistical result of PD-1 expression. Note: group A is the probiotic feeding group; group B is the nonprobiotic feeding group.

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