Probiotics Can Boost the Antitumor Immunity of CD8⁺T Cells in BALB/c Mice and Patients with Colorectal Carcinoma

Figure 5

Analysis of antitumor mechanism of CD8⁺T cells after probiotic intervention. After CT26 cells were inoculated subcutaneously on the back of BALB/c mice, they were fed with Bifidobacterium. After 3 days, the tumor tissues were removed and analyzed by flow cytometry. (a) The results of IFN-γ⁺CD8⁺TIL in the Bifidobacterium feeding group, (b) the results of IFN-γ⁺CD8⁺TIL in the non-Bifidobacterium feeding group, (c) the TNF-α⁺CD8⁺TIL in the Bifidobacterium feeding group, (d) the results of TNF-α⁺CD8⁺TIL in the non-Bifidobacterium feeding group, (e) the statistical results of IFN-γ⁺CD8⁺T cells between group A and group B, and (f) the statistical results of TNF-α⁺CD8⁺T between group A and group B. Note: group A is the probiotic feeding group; group B is the nonprobiotic feeding group.

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