Blocking Interleukin-33 Alleviates the Joint Inflammation and Inhibits the Development of Collagen-Induced Arthritis in Mice

<div>Anti-IL-33 treatment of mice with CIA resulted in reduced joint pathology. (a) On day 43, mice were killed and knee joints were collected and stained with HE. The inflammatory infiltrate, cartilage destruction, and bone erosion were observed in the control IgG-treated mice (arrows). P: patella; S: synovium; H: hyperplasia; JS: joint space; C: cartilage; F: femur. Magnification: ×40. (b) Anti-IL-33 antibody treatment alleviated the joint damage. The histological features of synovial bone erosion, hyperplasia, and cell infiltration were evaluated. 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Journal of Immunology Research

fig3

Figure 3

Figure 3: Blocking Interleukin-33 Alleviates the Joint Inflammation and Inhibits the Development of Collagen-Induced Arthritis in Mice 