Research Article
Thymic Stromal Lymphopoietin Is Implicated in the Pathogenesis of Bullous Pemphigoid by Dendritic Cells
Figure 3
DC-SIGN-positive DCs infiltrated in the dermis of the skin from patients with BP more extensively than those of the HCs’ skin. (a) Staining with DC-SIGN (green) and DAPI (blue) showed DC-SIGN-positive DCs (white arrowheads) distinctively infiltrated in the dermis of the BP lesional skin. (b) In the skin of HCs, there are hardly any DC-SIGN-positive DCs. Results from three patients with BP and three HCs are shown in (a, b), respectively. Dashed white lines indicate the basement membrane zone or edge of blister. Asterisks () indicate the area of blisters. Original magnification: ×100 and ×200, BP: bullous pemphigoid; DAPI: 4,6-diamino-2-phenyl indole; DCs: dendritic cells; DC-SIGN: dendritic cell–specific intercellular adhesion molecule-3-grabbing nonintegrin; HCs: healthy controls.
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