Innate Immune Effectors Play Essential Roles in Acute Respiratory Infection Caused by Klebsiella pneumoniae

Figure 5

Depletion of innate immune effectors exacerbated K. pneumoniae lung infection. Mice () were infected intratracheally with CFUs of strain YBQ and blood and lungs were collected 24 h after infection. (a) Survival curves for neutrophil, macrophage, and complement depleted mice were monitored for 7 days. (b) Bacterial burdens in the lungs and blood for different groups were counted on Luria-Bertani (LB) plates. (c) 24 hours after infection, lung tissues in each group were collected, and lung sections were stained with hematoxylin-eosin, and histopathology of different groups was evaluated (). Statistical analyses were performed by Student’s test. () and () compared to control mice.

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