Research Article
Genetic Mutations of Tim-3 Ligand and Exhausted Tim-3+ CD8+ T Cells and Survival in Diffuse Large B Cell Lymphoma
Table 1
Association between Tim-3 expression on TILs and clinicopathologic parameters.
| | Parameters | (%) | Tim-3- TILs | Tim-3+ TILs | value |
| | Sex | | | | | | Female | 67 (50) | 30 (44.8) | 38 (56.7) | 0.167 | | Male | 67 (50) | 38 (55.2) | 29 (43.3) | | | Age (years) | | | | | | ≤60 | 82 (67.7) | 38 (56.7) | 44 (65.7) | 0.287 | | >60 | 52 (32.3) | 29 (43.3) | 23 (34.3) | | | B symptom | | | | | | Yes | 107 (86.2) | 55 (82.1) | 52 (77.6) | 0.518 | | No | 27 (13.8) | 12 (17.9) | 15 (22.4) | | | Clinical stage | | | | | | I-II | 64 (47.8) | 38 (56.7) | 26 (38.8) | 0.038 | | III-IV | 70 (52.2) | 29 (43.3) | 41 (61.2) | | | IPI scores | | | | | | 0-2 | 95 (73.8) | 53 (79.1) | 42 (62.7) | 0.036 | | 3-5 | 39 (26.2) | 14 (20.9) | 25 (37.3) | | | LDH | | | | | | Normal | 82 (55.4) | 47 (70.1) | 35 (52.2) | 0.033 | | High | 52 (44.6) | 20 (29.9) | 32 (47.8) | | | Subtypes | | | | | | GCB | 44 (32.8) | 22 (32.8) | 22 (32.8) | 1.000 | | Non-GCB | 76 (56.7) | 38 (56.7) | 38 (56.7) | | | Unclassified | 14 (10.4) | 7 (10.4) | 7 (10.4) | |
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