The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars

Figure 5

Histological analysis of the effect of topical FTY720 injection on Day 14 cross-sectional scar formation. (a) Representative Masson’s trichrome stain images of the histological scar area (dotted line) are shown. The average cross-sectional scar areas were plotted (scale bars: 500 μm, ). (b) Quantification of scar elevation index (SEI). “” indicates scar thickness, and “” indicates adjacent normal skin thickness. SEI is defined by the ratio (). (c) Representative images under high magnification and quantification of the percentage of collagen area and collagen integrated density (scale bars: 20 μm, ). Two independent experiments were performed. Both showed similar results. The values shown represent , as determined by Student’s -test or Welch’s -test after test.

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