Successful Regulatory T Cell-Based Therapy Relies on Inhibition of T Cell Effector Function and Enrichment of FOXP3+ Cells in a Humanized Mouse Model of Skin Inflammation

Figure 3

Treg infusion inhibits skin-infiltrating T cells and downregulates local IL-17 production while promoting FOXP3+ Treg enrichment. Representative histology at 10x magnification and quantitative analysis in skin grafts from SCID beige mice at 28 days after cell injection. Expression of human (a) CD4+ and (b) CD8+ T cells. (c) Expression of IL-17-secreting cells and (d) expression of CD3+ (blue) and FOXP3 (red). is shown for (a–c) (). Statistical significance was analysed by the Mann–Whitney test. value < 0.05; value < 0.01.