Immunotherapy with IgY Antibodies toward Outer Membrane Protein F Protects Burned Mice against Pseudomonas aeruginosa Infection
Table 1
The effect of different regimens of anti-OprF IgY antibodies on the survival of P. aeruginosa-infected mice (). Survival was assessed in infected mice with burn wounds days after subcutaneous injection of P. aeruginosa.
Group
Challenge
Intravenous treatment
No. of dead mice/total no. of mice on day
Survival (%)
1
2
3
4
5
I
Neutralized P. aeruginosa with 0.1 mg of anti-OprF IgY
—
1/8
6/8
6/8
6/8
6/8
25
II
Neutralized P. aeruginosa with 10 mg of anti-OprF IgY
—
0/8
0/8
4/8
6/8
6/8
25
III
Neutralized P. aeruginosa with 1 mg of anti-OprF IgY
0.5 mg of anti-OprF IgY (12 h after infection)
0/8
2/8
4/8
4/8
4/8
50
IV
Prophylaxis 1 mg of anti-OprF IgY 2 h before infection with P. aeruginosa
0.5 mg of anti-OprF IgY (12 h and 24 h after infection)
0/8
0/8
1/8
1/8
1/8
87.5
V
Neutralized P. aeruginosa with 1 mg of control IgY
