Increased Frequencies of Switched Memory B Cells and Plasmablasts in Peripheral Blood from Patients with ANCA-Associated Vasculitis

Table 3

Concentrations of IgA, IgG, and IgM in patients with AAV.

Concentration (g/L)	IgA	IgG	IgM
AAV patients ()^a	1.86 (1.32-2.75)	10.1 (8.46-12.9)	0.83 (0.60-1.33)
Diagnosis
GPA ()^a	1.80 (1.40-2.75)	9.99 (8.60-12.9)	0.83 (0.61-1.42)
MPA ()	1.86 (1.31-2.67)	10.1 (7.66-12.6)	0.73 (0.58-1.23)
EGPA ()	3.74 (0.73-5.12)	11.7 (10.4-15.6)	1.51 (0.33-2.81)
Disease activity
Active disease ()^a	1.99 (1.57-2.68)	9.79 (8.31-13.0)	0.72 (0.37-1.18)
Remission ()	1.86 (1.23-2.77)	10.4 (8.50-12.8)	0.83 (0.63-1.39)
Tendency to relapse
Yes ()^a	1.80 (1.43-2.41)	9.88 (7.76-12.0)	0.98 (0.59-1.32)
No ()	2.02 (1.32-3.52)	11.4 (9.47-13.7)	0.75 (0.63-1.45)
Treatment
AAV with ≥1 drugs ()^a	1.79 (1.38-2.44)	9.32 (7.75-12.4)	0.77 (0.54-1.30)
AAV no medication ()	2.82 (1.20-4.50)	12.0 (9.95-13.7)	0.96 (0.72-1.50)

Concentrations of IgA, IgG, and IgM in patients with AAV. Data are presented with medians and interquartile ranges. Ig: immunoglobulin; AAV: antineutrophil cytoplasmic autoantibody- (ANCA-) associated vasculitis; GPA: granulomatosis with polyangiitis; MPA: microscopic polyangiitis; EGPA: eosinophilic granulomatosis with polyangiitis. Reference range IgA 0.88-4.5 g/L, IgG 6.7-14.5 g/L, and IgM 0.27-2.1 g/L. ^aFor one patient, only IgG and IgM were measured. The Mann-Whitney test was used to calculate the level of significance. Subgroups of were not included in the statistical analyses. Denotes statistical difference as compared to comparator patient subgroup (listed below in the table).