Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population
Table 2
The genotypes and allele frequencies in the studied groups.
Gene
SNV
Genotypes/allele
MS ()
HC ()
OR (95% CI)
Frequency
Frequency
IL2RA
rs7093069
CC
57
(60.64%)
69
(43.12%)
NS
CT
36
(38.8%)
83
(51.88%)
0.016
0.52
TT
1
(1.06%)
8
(5.0%)
0.047
0.15
C
150
(0.80)
221
(0.69)
0.0053
0.56
T
38
(0.20)
99
(0.31)
rs12722598
TT
80
(85.11%)
156
(97.5%)
NS
TC
14
(14.89%)
3
(1.88%)
0.06
4.2
CC
—
1
(0.62%)
NS
T
174
(0.93)
315
(0.99)
0.001
0.2
C
14
(0.07)
4
(0.01)
CTLA4
rs3087243
GG
0
(0.00%)
69
(43.12%)
0.00
0.0038
GA
30
(31.91%)
77
(48.12%)
0.00
0.087
AA
64
(68.09%)
14
(8.75%)
NS
G
30
(0.16)
215
(0.67)
0.00
0.09
A
158
(0.84)
105
(0.33)
rs231775
AA
36
(38.30%)
51
(31.88%)
NS
AG
45
(47.87%)
82
(51.25%)
NS
0.78
GG
13
(13.83%)
27
(16.88%)
NS
0.68
A
117
(0.62)
184
(0.58)
NS
G
71
(0.38)
136
(0.43)
rs5742906
CC
71
(75.53%)
109
(68.13%)
NS
CT
20
(21.28%)
40
(25.00%)
NS
0.77
TT
3
(3.19%)
11
(6.88%)
NS
0.41
C
162
(0.86)
258
(0.81)
0.069
T
26
(0.14)
62
(0.19)
CD40
rs1883832
TT
7
(7.45%)
10
(6.25%)
NS
TC
23
(24.47%)
59
(36.88%)
0.0477
0.55
CC
64
(68.09%)
91
(56.88%)
NS
0.99
T
37
(0.20)
79
(0.25)
NS
C
151
(0.80)
241
(0.75)
PADI4
rs1748033
TT
7
(7.45%)
13
(8.13%)
NS
TC
45
(47.87%)
58
(36.25%)
0.068
1.64
CC
42
(44.68%)
89
(55.63%)
NS
1.14
T
59
(0.31)
84
(0.26)
NS
C
129
(0.69)
236
(0.74)
For genotypes, we report value for Chi2 test, and for alleles, we report Fisher’s exact value. SNV, single-nucleotide variant; MS, multiple sclerosis; HC, healthy control; OR, odds ratio.
