Interleukin-6 versus Common Inflammatory Biomarkers for Diagnosing Fracture-Related Infection: Utility and Potential Influencing Factors

Table 4

Discriminatory strengths of the four inflammatory biomarkers.

Infection markers	AUC	95% CI	Optimal cut-off value	Sensitivity	Specificity
WBC (×10^9/L)	0.569	0.522-0.617	9.3	16.7%	94.9%
ESR (mm/1 h)	0.765	0.725-0.806	8.5	72.7%	70.3%
CRP (mg/L)	0.764	0.724-0.804	2.7	65.6%	75.4%
IL-6 (pg/mL)	0.718	0.678-0.758	5.9	57.5%	83.6%

The optimal cut-off value was obtained by calculating the maximum Youden index ().