Polypeptide Globular Adiponectin Ameliorates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Necroptosis

Figure 6

gAd inhibits hypoxia/reoxygenation-induced necroptosis and apoptosis in cardiomyocytes by disrupting the p38/NF-κB signaling pathway. (a–g) Western blotting and average data of p38, NF-κB, Bcl-2, Bax, RIP1, RIP3, and (cleaved) caspase-3 protein abundance in the control, gAd, HR, HR+gAd, and HR+SB groups (). (h) Immunofluorescence double staining for NF-κB (green) localization. The nuclei of the cells were counterstained with Hoechst (blue) (, scale bar, 50 μm). (i) The bar figures show the quantification data on NF-κB translocation. and vs. the control group; ^# vs. the H/R group.

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