Research Article

Association between Sleep Traits and Lung Cancer: A Mendelian Randomization Study

Table 2

Two-sample Mendelian randomization estimations showing the effect of sleep traits on cancer using the IVW method.

ExposureMethodOR (95% CI) value

ChronotypeInverse variance weighted0.90 (0.70-1.16)0.42
MVMR adjusted for pack years for smoking0.90 (0.68-1.19)0.46
MVMR adjusted for current tobacco smoking0.92 (0.71-1.18)0.50
Getting up in the morningInverse variance weighted0.99 (0.62-1.60)0.98
MVMR adjusted for pack years for smoking1.18 (0.66-2.12)0.57
MVMR adjusted for current tobacco smoking1.30 (0.80-2.10)0.29
Sleep durationInverse variance weighted0.46 (0.26-0.83)0.01
MVMR adjusted for pack years for smoking0.47 (0.25-0.90)0.02
MVMR adjusted for current tobacco smoking0.53 (0.31-0.90)0.02
Nap during the dayInverse variance weighted1.37 (0.77-2.44)0.29
MVMR adjusted for pack years for smoking1.04 (0.53-2.01)0.92
MVMR adjusted for current tobacco smoking1.17 (0.66-2.07)0.60
SleeplessnessInverse variance weighted2.53 (1.25-5.12)0.01
MVMR adjusted for pack years for smoking1.64 (0.59-4.59)0.34
MVMR adjusted for current tobacco smoking1.94 (0.99-3.79)0.05
ChronotypeInverse variance weighted0.87 (0.59-1.27)0.46
MVMR adjusted for pack years for smoking0.83 (0.57-1.21)0.33
MVMR adjusted for current tobacco smoking0.86 (0.59-1.24)0.42
Getting up in the morningInverse variance weighted1.08 (0.55-2.12)0.82
MVMR adjusted for pack years for smoking1.20 (0.59-2.43)0.61
MVMR adjusted for current tobacco smoking1.20 (0.60-2.38)0.61
Sleep durationInverse variance weighted0.46 (0.18-1.18)0.11
MVMR adjusted for pack years for smoking0.50 (0.21-1.19)0.12
MVMR adjusted for current tobacco smoking0.57 (0.25-1.30)0.18
Nap during the dayInverse variance weighted1.07 (0.48-2.35)0.87
MVMR adjusted for pack years for smoking0.81 (0.36-1.80)0.60
MVMR adjusted for current tobacco smoking0.86 (0.39-1.88)0.70
SleeplessnessInverse variance weighted2.46 (0.83-7.34)0.11
MVMR adjusted for pack years for smoking1.36 (0.43-4.24)0.60
MVMR adjusted for current tobacco smoking1.76 (0.70-4.41)0.23
ChronotypeInverse variance weighted0.85 (0.61-1.20)0.37
MVMR adjusted for pack years for smoking0.83 (0.57-1.20)0.32
MVMR adjusted for current tobacco smoking0.86 (0.60-1.22)0.39
Getting up in the morningInverse variance weighted1.60 (0.73-3.49)0.24
MVMR adjusted for pack years for smoking2.01 (0.89-4.55)0.10
MVMR adjusted for current tobacco smoking2.03 (0.95-4.33)0.07
Sleep durationInverse variance weighted0.62 (0.29-1.31)0.21
MVMR adjusted for pack years for smoking0.63 (0.28-1.43)0.27
MVMR adjusted for current tobacco smoking0.70 (0.34-1.43)0.32
Nap during the dayInverse variance weighted1.67 (0.72-3.87)0.23
MVMR adjusted for pack years for smoking1.20 (0.48-2.99)0.70
MVMR adjusted for current tobacco smoking1.56 (0.67-3.65)0.30
SleeplessnessInverse variance weighted5.75 (2.12-15.65)<0.01
MVMR adjusted for pack years for smoking4.55 (1.23-16.87)0.02
MVMR adjusted for current tobacco smoking4.99 (1.79-13.90)<0.01

OR: odds ratios; 95% CI: 95% confidence interval; IVW: inverse variants weighted; MVMR: multivariable variant Mendelian randomization.