Immunomodulatory Effects of Canine Adipose Tissue Mesenchymal Stem Cell-Derived Extracellular Vesicles on Stimulated CD4<sup>+</sup> T Cells Isolated from Peripheral Blood Mononuclear Cells

<div>Proliferative ability of PBMCs cocultured with cADSC-EVs. (a) Proliferation of PBMCs was assayed using the CFSE method by flow cytometry. Segments represent the percentages of PBMC proliferation. (b) Comparison of proliferative PBMCs treated with various concentrations (1, 5, and 10 <i>μ</i>g/ml) of naive or primed cADSC-EVs. The inhibitive effects on PBMCs were not different between naive and primed EVs at the same concentrations. 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124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,50.025,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>,</span> between groups.</div>

Journal of Immunology Research

fig3

Figure 3

Figure 3: Immunomodulatory Effects of Canine Adipose Tissue Mesenchymal Stem Cell-Derived Extracellular Vesicles on Stimulated CD4<sup>+</sup> T Cells Isolated from Peripheral Blood Mononuclear Cells 

Figure 3 | Immunomodulatory Effects of Canine Adipose Tissue Mesenchymal Stem Cell-Derived Extracellular Vesicles on Stimulated CD4+ T Cells Isolated from Peripheral Blood Mononuclear Cells 