Research Article

Inhaled [D-Ala2]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung Injury

Figure 4

The treatment with leytragin increases SIRT1 mRNA levels in the lungs of LPS-induced mice. The relative levels of SIRT1 mRNA transcription in the lungs of mice that received leytragin were significantly higher than those in the control group; 75 animals per group were used (5 per indicated time point); and vs. LPS+saline, two-way ANOVA, and post hoc Bonferroni’s test (see the text). Bars represent the .