lncRNA OIP5-AS1 Suppresses Cell Proliferation and Invasion of Endometrial Cancer by Regulating PTEN/AKT via Sponging miR-200c-3p

Figure 7

A schematic diagram depicts the molecular basis of OIP5-AS1/miR-200c-3p/PTEN in EC cells. In EC cells, the level of OIP5-AS1 was downregulated, which could promote the proliferation and invasion of EC in vivo and in vitro. Meanwhile, miR-200c-3p was the direct target of OIP5-AS1 and upregulated in EC cells, which was also related to the progression of EC. Notably, we found the miR-200c-3p could inhibit the expression of PTEN, which was the inhibitor of the AKT pathway. Taken together, we found a novel molecular mechanism that lncRNA OIP5-AS1 could act as a ceRNA to regulate PTEN by sponging the miR-200c-3p.