Salivary and Serum Interleukin-10, C-Reactive Protein, Mean Platelet Volume, and CRP/MPV Ratio in the Diagnosis of Late-Onset Neonatal Sepsis in Full-Term Neonates

Table 3

ROC curves for salivary and serum IL-10, MPV, and CRP/MPV ratio to predict late-onset sepsis.

Parameter	AUC	SE	95% CI	Cutoff value	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
MPV (fL)	0.999	0.001	0.99-1	≥9.2	100	94.3	94.6	100
CRP/MPV ratio	1	0.000	1-1	≥0.90	100	97.1	97.2	100
Serum IL-10 (pg/ml)	0.97	0.024	0.92-1	≥33.6	97.1%	80	82.9	96.6
Salivary IL-10 (pg/ml)	0.994	0.005	0.98-1	≥31	97.1	94.3	94.4	97.1

MPV: mean platelet volume; CRP: C-reactive protein; IL-10: interleukin 10; PPV: positive predictive values; NPV: negative predictive value.