The Ablation of Envelope Protein Glycosylation Enhances the Neurovirulence of ZIKV and Cell Apoptosis in Newborn Mice

Figure 2

Envelope protein glycosylation ablation enhances the neurovirulence of ZIKV in neonatal mice. (a) The changes of body weight. , . (b) Survival rate in neonatal mice after viral copies of ZKC2P4/ZKC2P6 infection or the uninfected supernatant injection. , . (c) Body length and posture of neonatal mice at 3 and 5 DPI. . (d) Brain weight of neonatal mice. , , , and . (e) Microcephalic brains from mice in the ZKC2P4 and ZKC2P6 groups. Black bars represent the brain width or cerebral cortex length, scale bar: 0.5 cm. (f) Brain cortices and (g) histopathological analysis of the cerebral cortex, hippocampus, and cervical spinal cord in each group at 5 DPI. Nissl staining, scale bar: 100 μm.

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