The Ablation of Envelope Protein Glycosylation Enhances the Neurovirulence of ZIKV and Cell Apoptosis in Newborn Mice

Table 1

Lesions of cervical spinal cord, kidney, and parts of brain on 3 and 5 DPI.

DPI	Group	Cerebral cortex	Hippocampus	Cerebellum	Brain stem	Cervical spinal cord	Kidney
3	Mock	-	-	-	-	-	-
	ZKC2P4	+	+	+	-	±	-
	ZKC2P6	++	++	+	+	±	-
5	Mock	-	-	-	-	-	-
	ZKC2P4	++	+	+	±	±	-
	ZKC2P6	+++	+++	++	+	+	-

Note: -, no lesions and inflammation/necrosis; ±, minor lesions, occasional neurons/glial cell inflammation and necrosis; +, mild lesions, a few neurons/glial inflammation and necrosis; ++, moderate lesions, more neurons/glial cell inflammation and necrosis; +++, severe lesions, large number of neurons/glial inflammation and necrosis.