Deficiency of IKK<i>α</i> in Macrophages Mitigates Fibrosis Progression in the Kidney after Renal Ischemia-Reperfusion Injury

<div>Gross kidney morphology and renal function of WT and Mac IKK<i>α</i>−/− mice after IRI. (a) Gross images of kidneys from WT and Mac IKK<i>α</i>−/− mice at day 3, day 7, day 14, and day 21 after renal IRI. The IRI kidneys of WT mice were smaller and atrophic compared with kidneys of Mac IKK<i>α</i>−/− mice after day 7 following renal IRI. (b) The weight of injured kidneys indicated the extent of atrophy, and the data showed that the kidneys of WT mice were significantly lighter than the kidneys of Mac IKK<i>α</i>−/− mice. (c, d) Creatinine and urea nitrogen levels in serum were measured 1 day after contralateral nephrectomy at the indicated time points. 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Journal of Immunology Research

fig2

Figure 2

Figure 2: Deficiency of IKK<i>α</i> in Macrophages Mitigates Fibrosis Progression in the Kidney after Renal Ischemia-Reperfusion Injury 

Journal of Immunology Research

Deficiency of IKKα in Macrophages Mitigates Fibrosis Progression in the Kidney after Renal Ischemia-Reperfusion Injury

Figure 2